Home Alzheimer's and Dementia Estrogen (oestrogen) mimics or gender benders or xenoestrogens

Estrogen (oestrogen) mimics or gender benders or xenoestrogens

Female health. Gender symbol made from pink red pills or tablets on wooden table

Estrogen mimics or ‘Gender benders’

Estrogen or oestrogen – it’s the female sex hormone, right?

Actually, not exactly. Oestrogen or estrogen, depending upon what side of the Atlantic you reside, is a family of hormones.

Family members

More correctly one, estrone, (oestrone), is made via the C-2 biochemical pathway in the ovaries. It is the female sex hormone. It attaches to cellular receptor sites and, like any hormone, delivers its functional message. Estrone declines as women enter menopause.

Unfortunately, there is another family member, made from your fat stores – yes, women and men too – by aromatase enzymes via the C-16 pathway. It is called estradiol (oestradiol) and sits on the same cellular receptor sites that estrone uses. However, estradiol creates havoc inside the cell, throwing out sodium and potassium levels, oxygen and acidity, and powering down the cell.

A third estrogen group within this ‘family’ are phytoestrogens typically found in vegetables and fruits particularly greens and pulses. They bind much more weakly to the same receptor sites, and are more easily washed through the body, so you need to eat them every day to block your receptors from attack by more dangerous members.

“There is a great book from Chris Woollams on this whole subject – Called ‘Oestrogen, the killer in our midst’ Click the book link on the right of this page to buy it”.

There are natural compounds that can have positive effects in regulating human estrogens –  for example, flaxseed, genestein (red clover), melatonin (the sleep hormone that regulates body estrogen, growth hormone, estrogen receptor sites and more), certain mushrooms, pulses and Indole 3 carbinol/DIM. Your gut bacteria and the amount of fibre you consume are also important. It’s all in the book.

Chemical mimics

Estrogen mimics, or xenoestrogens, are a group of different molecules that, in fact, do not seem to have many similarities.

However, they possess the ability to lock onto estrogen receptor sites on cells.

Some deliver messages of havoc into cells; whilst others may simply block the normal action of human estrogen from reaching the receptors.  The later group is more correctly termed estrogen antagonists. A third group of chemicals has been shown to damage hormone production in humans. Unfortunately a large proportion of these chemicals can by-pass the normal regulation systems of the body.

Their effects have been linked to decreases in male sperm counts, early puberty and rising rates of endometriosis particularly in younger women. They can lead to infertility. In the waters off California and in certain rivers hermaphrodite fish and frogs have been found; their condition has been linked to the estrogen mimic effects of pesticides. Xenoestrogens have also been linked to hormonally-driven cancers such as breast and prostate.

Dangers are ‘widespread and cumulative’

Of course there are Government ‘safe’ limits set for any ingredient. However, in the case of these hormone mimics, research from Dr. Ana Soto at Tufts, has shown that they are cumulative in the human body. There is no safe limit.

So how can humans avoid hormone mimics and gender benders. Here’s a ‘starter’ list of

How to avoid key estrogen mimics:

  1. Avoid certain pesticides, herbicides, insecticides

The most notorious case was that of DDT causing a 4-fold rise in breast cancer rates in Israel, over rates in Europe. This was tracked to the use of DDT and its entry into the food chain via grazing cattle. DDT and Lindane were subsequently ‘banned’ – but only from sale in the Western world. They are still made and sold to third world countries, for example in Africa and Asia, who now supply foods to Western markets!

Other common chemicals of concern include  organophosphates like carbendazim and endosulphan. The only real answer is to go organic and even ‘grow your own.

  1. Avoid certain preservatives like Parabens

Found in deodorants, toothpastes, shampoos, moisturisers and more. Often in ‘natural products’!

  1. Avoid plasticisers like Bisphenol A or BPA, (in plastic bottles, while can liners, toys), and phthalates (plastic bottles)

They especially occur when heat denatures the plastic and releases more chemicals into the liquids contained. Phthalates are also found in hair sprays, perfumes, nail polishes and more.

  1. Avoid suncreams contain oxybenzone, retinyl palmitate and PABA. And possibly phthalates from bottles left in the sun.
  2. Avoid direct contact with perfumed products. Perfumes rarely disclose the chemicals used. At the last count, 16 ingredients had been shown to be estrogen mimics.
  3. Beware the contraceptive pill and especially /oestrogen/progesterone HRT and even IVF.

Who needs the added estrogen?

  1. Drink clean water in cities

Many cities recycle their water but don’t have the filtration systems capable of removing the chemical estrogens in the water.

  1. Live clean in personal care products

A UK research study showed on average a woman comes into regular contact with over 600 chemical compounds – many are estrogen mimics.  For example, Toluene in some nail polishes, Xylene (Dimethyly benzene) in laquers and nail polishes, alkylphenol ethoxylates (hormone disrupters also linked to asthma) in shaving gels, hair colours.


Sadly, the list seems endless.

The only smart answer is to find a company that avoids ALL the chemicals of concern in personal care and in-home products.

CLICK HERE to find a company that we think is the really SMART CHOICE as it avoids ALL chemicals of concern in everyday products!