Diabetes, better glucose and lipid metabolism and obesity could be managed through a better balance between just four bacterial species, particularly by the addition of Lactobacillus johnsonii and Lactobacillus gasseri.
Researchers from Oregon State University lead by Associate Professors Andrey Morgun and Natalia Shutzhenko conducted two studies; a preliminary study with humans was followed by a detailed one with Mice.
The study sought to study sugar metabolism using a new data-driven, systems-biology approach called transkingdom network analysis to study host-microbe interactions.
Four species were discovered to be extremely important – two were considered glucose metabolism improvers (Lactobacillus johnsonii, Lactobacillus gasseri), and two were considered glucose metabolism worseners (Romboutsia ilealis and Ruminococcus gnavus).
Feeding a standard Western Diet to the mice, with addition of the two Lactobacillus strains, resulted in a
much improved liver mitochondrial metabolism, glucose and lipid metabolism, and a lower BMI. This was confirmed by the human group.
When looking at the Human research R. ilealis was found in over 80% of people with obesity. The researchers strongly believe that diabetes, glucose metabolism, lipid metabolism and obesity could be managed simply through the use of probiotics. A simple start might be taking the two Lactobacillus strains mentioned.
- Nature Communications: https://www.nature.com/articles/s41467-020-20313-x