The use of the common insecticide Ivermectin is associated with lower mortality during treatment of COVID-19, especially in patients with severe pulmonary involvement, and has been recommended by health experts to both prevent and treat Covid-19.
Previously, Ivermectin had shown promise with Covid-19 in vitro. In this study (1) the researchers followed 280 Covid-19 patients in four Broward Health Hospitals in Florida during the period of March 15th to May 11th 2020. Some were treated with Ivermectin, others not. Although dosing guidelines were provided, ultimately the Doctor in charge made the final decision.
Of the 280 patients, 173 were treated with Ivermectin, and 107 not. Most patients across both groups received either or both Hydroxychloroquine and azithromycin.
Mortality was 24.7% in the non-Ivermectin group but only 13.3% in the Ivermectin-treated patients. This was particularly marked in patients with severe pulmonary involvement with mortality down to 38.8% from 80.7% in the non-treated patients. No significant differences were found in length of stay.
Ivermectin is produced normally by the bacterium Streptomyces avermitilis and kills lice, worms, nematodes and mites by disrupting the fluid exchange through the insect’s cell membrane. The FDA approved the anti-helmintic drug in 2015, stating that it was ‘astonishingly safe’. In other studies it has even been shown to extend the effectiveness of chemotherapy drugs (2).
Paul Marik, MD, FCCM, FCCP, founder of the Frontline Covid-19 Critical Care Alliance and a professor and chief of the division of pulmonary and critical care medicine at Eastern Virginia Medical School, stated that ivermectin “is a safe drug that is exceedingly cheap. Ivermectin is highly active against Covid-19.”
Ivermectin protocol for Covid-19
The Alliance have a protocol using Ivermectin: the I-Mask+Protocol.
For prevention, in high risk people: 0.2 mg/kg on day 1 and day 3, and weekly for 4 weeks;
For people newly diagnosed: 0.2 mg/kg on day 1 and day 3.
Both groups receive daily doses of Vitamin D, Vitamin C, Quercetin, Zinc and Melatonin.
At a Press conference in December 2020, Marik presented all the studies on Ivermectin, including a randomized controlled trial from Egypt where, in healthcare workers wearing masks and taking Ivermectin only 2% became infected, whereas in those not taking Ivermectin it was 10%. Ivermectin cut infection by 80%.
Pierre Kory, MD, MPA, an associate professor of medicine and a critical care physician at St. Luke’s Medical Center in Milwaukee, said that since the Research paper had been finished, even more studies had come in showing the same benefits.
In India, a matched case-controlled study amongst health care workers in contact with Covid-19 patients between September and October 2020 showed a 73% reduction in infection in those taking two doses of Ivermectin. Protection lasted approximately one month (3).
In March 2021, a British panel of health experts – The Evidence Based Medical Consultancy – convened a meeting of Health experts from 16 countries, in Bath, who produced a meta-analysis of 20 research studies on Ivermectin. They called for the immediate use of Ivermectin in both treatment of, and prevention of Covid-19 (4).
In 6 randomized trials pulled together in a meta-analysis by Andrew Hill of Liverpool University, Ivermectin was shown to reduce Covid mortality by 75%. The research was funded by the WHO (5).
Ivermectin used effectively in India
Ivermectin works at two levels. It works at the initial anti-viral stage and then at the anti-inflammatory stage. A group of senior Doctors at the Academy of Medical Education published a paper in July 2020 evidencing that Ivermectin could be a preventative agent and treatment. They pointed out that it could be used alone, or in combination with other drugs, and it was safe and very inexpensive (6). Dr Surya Kent is not surprised that certain Indian states have chosen to ignore the World Health Organisation. The drug is being used to treat people in home isolation and also for prevention. One small pill every two weeks seems to stop the disease infecting people.
With infection, the drug reduces the replication rate of the disease by several thousand times, he stated. “Not only Uttar Pradesh, but governments of West Bengal, Andhra Pradesh, and Assam too included Ivermectin in their protocol for the treatment of COVID-19,” Dr Kent added and 8 Clinical Trials are taking place right now in India, brought on by the fact that those regions using Ivermectin have significantly lower rates of Covid and Covid death than the rest of India according to Statista (7).
The FDA have warned against the use of Ivermectin in Covid cases, saying there is a need for more clinical trials to see if “there are any other benefits to patients” (?). The NIH and the WHO take the same stance.
- Use of Ivermectin is associated with lower mortality in Hospitalized Covid-19 patients; Juliana Cepelowicz Rajter et al; Chest 2021; Jan 159 (1)DOI: 10.1016/j.chest.2020.10.009
- Ivermectin stops cancer drug resistance
- 3. India health workers Ivermectin study: https://www.medrxiv.org/content/10.1101/2020.10.29.20222661v1.full.pdf
- BIRD meeting of Worldwide Health Experts on Ivermectin https://covid19criticalcare.com/wp-content/uploads/2021/03/FLCCC-Release-on-BIRD-meeting-2021-03-09.pdf
- Meta-analysis on Ivermectin and Covid
- Dr Kent – the situation in India
- Statista India