The gut microbiome in patients with Skin Psoriasis has been found to be less diverse with four species of beneficial bacteria at lowered levels, than in the healthy microbiome of people without the disease.
In a 2015 study from researchers at New York Hospital, low levels of beneficial bacteria such as Coprococcus species, and Akkermansia, Ruminococcus and Pseudobutyrivibrio were found in patients with Psoriatic Arthritis, (PsA) and skin psoriasis, when compared with people without the disease. The researchers likened the changes in the gut microbiome to those seen in IBS.
“Supernatants of fecal samples from patients revealed an increase in sIgA levels and decrease in RANKL levels. Analysis of fatty acids revealed low fecal quantities of hexanoate and heptanoate in both patients with Psoriasis artritis and patients with psoriasis” states the abstract.
Gut bacteria are particularly susceptible to drugs, antibiotics, stress, smoking, infection, poor diet and chemical toxins. All of these will disrupt the microbiome. Many people find their psoriasis becomes worse in stressful situations.
Research has previously shown links with common chemicals, especially dioxins.
Chris Woollams, former Oxford University Biochemist said, “We are seeing this situation time and time again. Where doctors didn’t understand a disease fully they called it an autoimmune disease. But there’s no such thing really. Some beneficial bacteria prompt an anti-inflammatory immune response. If they are missing and/or there are pathogens around, you can produce an inflammatory immune response. That’s what is happening here.”
About 5 per cent of the population are thought to suffer from the disease, which has historically wrongly been thought to be largely genetic. According to Dr Jose Scher of New York Hospital, if a person has skin psoriasis, there is a 20-30% chance they will develop psoriatic arthritis.