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Coffee consumption halves Parkinson’s disease risk

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Coffee consumption halves Parkinson’s disease risk

Real coffee consumption has repeatedly shown a reduction in risk and progression of Parkinson’s Disease. 

Drinking four or five cups of real coffee a day cuts the risk of Parkinson’s Disease in men by almost a half. In women, the best reductions were seen with one to three cups per day (1).

Researchers at Harvard TH Chan Public School of Health went to the Health Professionals Follow-up Study, and the Nurses’ Health Study and looked at 10 years of data for men, and 16 for women. Over 135,000 people were selected for inclusion in the study.

In men, those drinking four or five cups had half the Parkinson’s occurrence and the findings were dose-dependent for caffeine (decaffeinated coffee had no effect). In Women, it was a U-shaped picture. No caffeine or too much, had no effect. Moderate consumption (defined as 1-3 cups of real coffee per day) had the most effect in reducing risk.

A second later study by lead author and neurologist Ronald Postuma, MD, MSc, at McGill University in Montreal with the Research Institute of the McGill University Health Center showed that real coffee might improve movement in Parkinson’s patients. Caffeine appeared to block a mal-functioning nerve signal in the brain (2).

In a 2020 review (3) on coffee and Parkinson’s reviewers stated that coffee’s action was via the brain’s Adenosine Receptor and confers ‘neuroprotection by modulating neuroinflammation and excitotoxicity and mitochondrial function’.

Another 2020 meta-study (4) reviewed 13 studies in all and concluded that ‘caffeine modified disease risk and progression in Parkinson’s disease, among both healthy individuals or those already with Parkinson’s disease.

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References:

  1. Prospective study of caffeine consumption and risk of Parkinson’s disease in men and women; A Asherio et al; Ann Neurol; 2001 Jul;50(1):56-63
  2. “Coffee may help some Parkinson’s disease movement symptoms, research suggests”; American Academy of Neurology; August 1, 2012 Science Daily
  3. Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms; Xiangpeng Ren and Jiang-Fan Chen; Front Neurosci. 2020; 14: 602697.
  4. The Effect of Caffeine on the Risk and Progression of Parkinson’s Disease: A Meta-Analysis; Nutrients. 2020 Jun; 12(6): 1860.